
On June 27, 2026, 67-year-old Alan Jackson walked onto the stage at Nashville’s Nissan Stadium in front of nearly 70,000 fans for *Last Call: One More for the Road – The Finale*, closing a 36-year touring career while raising more than $2.25 million for Charcot-Marie-Tooth disease research.
The road to that Saturday night in Tennessee began fifteen years earlier, in 2011, when doctors diagnosed the Newnan, Georgia native with Charcot-Marie-Tooth disease, a degenerative genetic nerve disorder with no approved treatment or cure. Jackson had inherited the condition from his father, Eugene “Daddy Gene” Jackson, and had watched his father, his grandmother, and his older sister lose strength and mobility in their lower legs as they grew older.
For ten years after his 2011 diagnosis, Jackson kept the medical news private and continued booking arena dates. As the neuropathy progressed and weakened his lower legs and feet, the 6-foot-4 singer who had spent the 1990s striding from one side of the stage to the other in faded jeans and a white Stetson began stumbling during sets.
By September 2021, when he sat down with Jenna Bush Hager on NBC’s *Today* show to make the condition public, Jackson explained that he had grown uncomfortable wondering if audiences watching him falter near the microphone stand assumed he had been drinking before the show. Although the nerve damage affected his balance and made playing acoustic guitar more difficult, the disorder is not fatal and left his baritone vocal cords untouched.
Rather than retreating immediately after the 2021 announcement, Jackson launched his *Last Call: One More for the Road* tour in 2022, playing reduced schedules of arena shows across the United States through May 2025. To turn those remaining dates into direct medical action, he partnered with the CMT Research Foundation, a 501(c)(3) nonprofit established in 2018 to fund scientific drug development and clinical trials for the three million people worldwide living with the condition.
For every ticket sold during the final tour stretch and the Nashville stadium concert, Jackson donated $1 to the CMT Research Foundation, while a group of anonymous donors stepped forward to match each contribution with an additional $2 per ticket. Inside the arenas, fans scanned codes and added individual contributions of their own, turning each stop into a briefing on a neurological condition many concertgoers had never heard of before walking through the turnstiles.
When Jackson announced on October 8, 2025, that Nissan Stadium would host the final full-length concert of his touring life, more than a dozen fellow artists cleared their schedules to appear. Before Jackson took the stage on June 27, 2026, Luke Combs, Carrie Underwood, Miranda Lambert, Eric Church, Keith Urban, Luke Bryan, Cody Johnson, Lainey Wilson, Riley Green, Jon Pardi, and Lee Ann Womack performed tributes to the songwriter who had earned 35 number-one hits and sold more than 75 million records.
Stepping out to open his headlining set with “Gone Country,” Jackson stood near center stage with a hand resting close to the microphone stand as he worked through 23 songs, including “Here in the Real World,” “Chasin’ That Neon Rainbow,” “Don’t Rock the Jukebox,” and “Remember When”. Midway through the night, George Strait walked out to join him side by side for “Designated Drinker” and their 2000 duet “Murder on Music Row”.
Later in the set, Jackson sang “Drive (For Daddy Gene),” the 2002 number-one single written for the father who had taught him to steer an old boat and a flatbed truck long before passing down the family’s genetic condition. Watching from the side of the stadium stage were Jackson’s wife of 46 years, Denise, and their three daughters, Mattie, Ali, and Dani, along with his grandchildren and extended relatives.
Days after the concert, eldest daughter Mattie wrote publicly that while she could not count how many shows she had watched across 36 years, seeing her father—whom his daughters and grandchildren call “Dado”—sing his final stadium set was a night the family would never forget. Filmed for an NBC television special and recorded for a live album, the evening closed with Jackson performing “Chattahoochee,” “Mercury Blues,” and “Where I Come From”.
On July 1, 2026, four days after the stadium lights went down in Nashville, the CMT Research Foundation announced that the $1 ticket deductions, the $2 donor matches, and fan gifts from Jackson’s farewell run had generated more than $2.25 million to advance laboratory treatments.
While the money raised across those final arenas arrived too late to restore the nerves in the 67-year-old singer’s legs, the $2.25 million went straight into clinical research aimed at stopping the inherited condition before it reaches the next generation, including the grandchildren who watched “Dado” take his final bow from the wings at Nissan Stadium.